Ivermectin nanoparticles shrink glioblastomas by 70 %

New hope in the fight against brain tumours

A Brazilian study shows an astonishing effect of ivermectin nanoparticles: in a preclinical study, a research team from Brazil has discovered a promising approach to treating brain tumours. Ivermectin, a well-known antiparasitic drug, was packaged in nanoparticles and administered directly via the nose. The results are impressive – in test animals, tumour volume was reduced by more than 70 %.

The study by the Universidade Federal do Rio Grande do Sul (UFRGS) tested two novel forms of administration: ivermectin in poly-ε-caprolactone nanocapsules (IVM-NC) and in mesoporous silica particles (IVM-MCM). The nanocapsule version (IVM-NC) was particularly effective: it crossed the blood-brain barrier and, in the animal model, led to a significant reduction of the tumour while being well tolerated. The daily dose was only 60 μg – around eight times less than in usual antiparasitic use.

Besides the tumour reduction, the surrounding brain tissue was also protected, with less swelling and abnormal vascular growth. In addition, no negative effects on the lungs or other organs were found.

Since glioblastoma is one of the most aggressive and difficult-to-treat brain tumours, this approach could represent an important new treatment option. However, the researchers stress that these are so far preclinical data – clinical studies in humans are essential as the next step.

This discovery is one of a growing number of research projects testing known drugs in new contexts. Whether ivermectin can actually gain a foothold in oncology remains to be seen – but the approach offers justified hope.

Source links (German)

• Success in cancer treatment: ivermectin nanoparticles destroy brain tumour cells
• Ivermectin shows impressive potential against cancer and remarkable safety
• Ivermectin, fenbendazole and mebendazole in cancer: peer-review protocol 2024

Oncologist: ivermectin cures cancer even at a late stage

Do you know this medication that everyone called a “horse dewormer”? It has multiple anti-cancer effects.

Dr. Kathleen Ruddy has seen several late-stage cancer patients show dramatic improvements after taking ivermectin.

One patient was in very bad shape – and then something amazing happened …pic.twitter.com/eyPRjxSDVl

— RiftTV (@TheRiftTV) May 15, 2024

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